CASP3 and neoplasm: Diels (A. sinensis) polysaccharide can remarkably suppress HeLa and lung cancer cell proliferation and tumor growth in transplanted sarcoma-180 mice [92], associated with induction of tumor cell apoptosis by activating internal mitochondrial pathways, such as Bcl-2 family protein expression regulation, mitochondrial membrane disruption, increased levels of cytosolic cytochrome c, and improved caspase-9 and caspase-3 activities.