Bi-allelic mutations in glucocerebrosidase 1 (GBA1; encoding glucocerebrosidase or GCase) cause Gaucher's disease, a lysosomal storage disorder (LSD), whereas heterozygous mutations are the most common and strongest genetic risk factor for sporadic PD, with a prevalence of ∼5-20% depending on the population investigated (Siebert et al., 2014; Orr-Urtreger et al., 2009; Neumann et al., 2009). This evidence concerns the gene GBA1 and Parkinson disease.