LCN2 and triple-A syndrome: In AAA, LCN2 has been described as having disease-promoting effects.26,27 LCN2 has diverse functions, many of which could contribute to AAA, including its neutrophil-chemotactic properties and its inhibitory effect on reparative autophagy.28–32 Consistent with these known functions of LCN2, we saw heightened neutrophil infiltration (Figure S4A and S4B) and impaired autophagy (Figure 4C through 4F) in Ang-II-treated hampfl/fl, SMMHC-CreERT2+ mice compared with hampfl/fl controls; effects that were prevented by neutralization of LCN2.