To aid comparison, data from saline or AngII-treated hampfl/fl or hampfl/fl, SMMHC-CreERT2+ mice shown previously in Figure 2 are shown again, where appropriate, in Figure 4G through 4L. Together, these data demonstrate that suppression of local LCN2 expression contributes to the protective effect of raised SMC-derived HAMP in the setting of AAA, and that this protective effect likely involves promoting reparative autophagy in SMCs and reducing neutrophil infiltration into the aortic wall. Here, LCN2 is linked to triple-A syndrome.