KCNJ5 and neoplasm: In a meta-analysis study including 13 studies and 1636 patients, the patients with KCNJ5 somatic mutations were significantly younger (45 ± 3 vs 52 ± 5 years), predominantly female (67% vs 44%), and had higher aldosterone level (42 ± 8 vs 33 ± 8 ng/dl), and larger tumor size (16.1 ± 6.4 versus 14.9 ± 7.4 mm) (71).