KCNJ5 and metabolic syndrome: In conclusion, KCNJ5 somatic mutations in patients with APA play an important role in cardiovascular outcomes (Figure 2), including higher LVM, more impaired diastolic function, thicker aortic wall, lower incidence of MetS, and possibly a lower incidence of concurrent ACS, but better improvement in LVM, diastolic function, arterial stiffness, and aortic wall thickness after adrenalectomy compared to patients without KCNJ5 mutations.