CX3CL1 and neoplasm: Furthermore, we observed higher levels of infiltrating macrophages (M0, M1) in the tumor microenvironment of patients with higher CDK1 expression, suggesting that CDK1 might recruit macrophages by upregulating the CCL26/CCR3 pathway and shift TAMs from the M2 to the M1 phenotype by downregulating CX3CL1/CX3CR1 pathway activity.