According to the experimental results, CXCL2 and JUN were downregulated in IL-1β-stimulated chondrocytes while conversely, ATF3 and TFRC were upregulated, which is opposite from the results of bioinformatics analysis, probably due to the fact that osteoarthritis patients from GSE55235 and GSE55457 datasets received non-steroidal anti-inflammatory drugs or the sequencing deviations. The gene discussed is CXCL2; the disease is osteoarthritis.