Several lncRNAs, located on the antisense strand of a paired protein-coding gene (and often named after the protein coding gene, including an ‘–AS’ ending) have been linked to glioma: high levels of PTB-AS (Zhu et al., 2019), ZEB1-AS1 (Meng et al., 2018), HMMR-AS1 (Bao et al., 2021) promoted migration and proliferation in glioma, negatively impacting patient survival rates, while ST7-AS1 (Sheng et al., 2021) was associated with prolonged patient survival acting as a tumor suppressor. The gene discussed is ZEB1; the disease is central nervous system cancer.