For example, in mouse models of CRC, colonization by Helicobacter hepaticus induced an increase in the number of colonic CD4 Tfh cells and promoted the maturation of tumor-adjacent tertiary lymphoid structures, increased cytotoxic lymphocyte infiltration in tumor, and inhibited tumor growth (Overacre-Delgoffe et al., 2021). The gene discussed is CD4; the disease is neoplasm.