A potent NF-κB inhibitor, triggers apoptosis of CRC cells through the TLR4/NF-κB signaling pathway, inhibits their migration, downregulates PD-L1 expression and myeloid-derived suppressor cell (MDSC) ratio, and upregulates CD4+ and CD8+T cell ratios. The gene discussed is TLR4; the disease is colorectal carcinoma.