An important role for Panx1 in inflammation has been observed especially for endothelial cells, because Panx1 at the plasma membrane of these cells mediates vascular inflammation during lung ischemia-reperfusion injury (Sharma et al., 2018) and regulates cardiac responses to acute myocardial infarction (Good et al., 2021). This evidence concerns the gene PANX1 and acute myocardial infarction.