These hTERT-specific TH1 cells migrate to tumors, where they stimulate the activity of CD8+ T cells against hTERT-expressing cancer cells or directly kill cancer cells by releasing cytokines, FAS, or tumor necrosis factor-associated apoptosis-inducing ligand (TRAIL) apoptosis-inducing receptor interactions (Ahmed and Tollefsbol, 2003). The gene discussed is CD8A; the disease is cancer.