NLRP3 and infection: Activation of complex signaling cascades such as the NLR family pyrin domain containing 3 (NLRP3) inflammasome can be triggered by a wide range of factors including cellular stress, infection (Bader and Winklhofer, 2020; Mahboubi Mehrabani et al., 2022), protein aggregates, and activated microglia (Nichols et al., 2019; Bader and Winklhofer, 2020; Tansey et al., 2022).