EIF2AK3 and Parkinson disease: Interestingly, it has been demonstrated that PERK inhibitor GSK2606414 (Figure 1, Table 2), despite its pancreatic toxicity (Halliday et al., 2015), inhibits and reduces PERK expression, which has a neuroprotective effect on DA neurons in Substantia Nigra pars compacta (SNpc) of PD mouse models, and improves the motor performance and neuronal excitability of PD mice (Mercado et al., 2018).