Although multiple animal models have been used to study preterm brain injury, such as IL-1β or LPS systemic injection-induced diffuse white matter injury in neonatal rodents (Favrais et al., 2011; Fan et al., 2013), ibotenic acid injection-induced white and gray matter injury in P5 mice (Sárközy et al., 2007), collagenase injection-induced intracranial hemorrhage in P5 rats (Jinnai et al., 2020), and HI-induced brain injury in P5 mice (Albertsson et al., 2014), none of them fully represent the pathology of brain injury seen in preterm infants. Here, IL1B is linked to intracranial hemorrhage.