According to the literature, ZAG has been found in a variety of tumors including oropharyngeal, esophageal, gastric, breast, prostate, pancreas, and liver tumours.9-11 The up-regulation of ZAG in various cancers was observed in early tumor stages, which was associated with a longer disease free survival and overall survival rate.11-13 There is a discrepancy in the literature about ZAG expression in tumors and its role as an early diagnostic marker. This evidence concerns the gene AZGP1 and neoplasm.