AZGP1 and neoplasm: According to studies, high expression of ZAG is associated with elimination of mutated RNAs and their by-products, as well as the down-regulation of cyclin-dependent kinase 2 (rate limiting enzymes) in the cell cycle.11 The enzyme is required to regulate the G2-M phase of the cell cycle, and by doing so, it may contribute to the inhibition of tumor cell growth.