Experiments on mice showed that the expression level of interleukin in mice with septic shock and sepsis was significantly increased.7 HMGB-1 is an inflammatory mediator with a variety of biological effects such as mediating inflammatory response and regulating gene transcription, which plays a vital role in the occurrence and progression of sepsis.8 Currently, there are still studies exploring the role of IL-35 levels in patients with sepsis, but very few studies on the correlation between SII and HMGB-1 levels and sepsis have been carried out. This evidence concerns the gene HMGB1 and Sepsis.