Beyond known T-ALL drivers (such as Runx1, Lef1, Bcl11b, and Rasgrp1), this list includes genes with a role in T cell biology (Satb1 and Rag2) as well as developmental genes for which a function in T cells has not been described before (such as Sall3 and the Hoxd cluster). Here, BCL11B is linked to T-cell acute lymphoblastic leukemia.