IL6 and acute lymphoblastic leukemia: We first compared the two largest clusters using gene set enrichment analysis (Figure 6C) and found enrichment of signatures characteristic for human ETP-ALL in one group (e.g., IL6/Jak/Stat), while the second group was enriched for cell-cycle-associated genes, a characteristic of human non-ETP T-ALL (hereafter referred to as “classical” T-ALL).67