Figure 1A displays the top 50 CIS genes, including: (1) known T-ALL drivers (such as Notch1, Pten, or Bcl11b),42 (2) genes that have not been linked to T-ALL before, but to other hematologic malignancies (e.g., Cux1, Mecom, Crebbp), and (3) genes that have not yet been associated with hematopoietic cancers so far. This evidence concerns the gene NOTCH1 and acute lymphoblastic leukemia.