NOTCH1 and in situ carcinoma: Figure 1A displays the top 50 CIS genes, including: (1) known T-ALL drivers (such as Notch1, Pten, or Bcl11b),42 (2) genes that have not been linked to T-ALL before, but to other hematologic malignancies (e.g., Cux1, Mecom, Crebbp), and (3) genes that have not yet been associated with hematopoietic cancers so far.