TP53 and familial pancreatic carcinoma: Despite significant concordance between mutation status and perturbations in the TP53-associated module (hypergeometric p = 8.8 × 10−4), we observed that patients with pancreatic cancer stratified based on MPS had significantly more divergent survival trajectories (Kaplan-Meier [KM] p = 2.5 × 10−5; hazard ratio = 0.33) than patients stratified based on the mutation status of TP53 (KM p value = 0.28; hazard ratio = 0.76; Figure 1D).