KCNE1 and heart disorder: An example of a drug target for cardiac disease detected in primary cardiomyocytes but not in hPSC-CMs is KCNE1 (azimilide), which has implications for FDA-mandated drug testing for blocking of the HERG channel, because of the risk to patients for torsades de pointes, a life-threatening polymorphic ventricular tachycardia.