Yamada et al. and Calcagno et al. performed spatio-temporal transcriptomic profiling of a mouse myocardial infarction (MI) model, and revealed activation of mechanosensing pathway in cardiomyocytes, characterized by high expression of Csrp3 and Flnc, at the border zone in acute phase after MI (42, 43). Here, CSRP3 is linked to myocardial infarction.