We were also able to focus on the major macrophage and SMC subtypes, and the results suggest that a proliferating macrophage subpopulation has the highest expression of Ak148321. Out of the plaque SMCs, the transitioning SMCs had the highest expression of Ak148321. For human atherosclerosis, we analyzed the scRNA sequencing data of human coronary plaques from Wirka et al. (14) and found that ANRIL expression was highest in T-cells and B-cells, followed by macrophages (Figure 5C). The gene discussed is CDKN2B-AS1; the disease is atherosclerosis.