To evaluate the impact of Cdkn2a and Cdkn2b in atherosclerosis and the regulation of macrophage phenotype in the Chr4Δ70kb/Δ70kbLdlr−/−ApoB100/100 mouse model, we measured the expression of Cdkn2a and Cdkn2b in Chr4Δ70kb/Δ70kb and Ldlr−/−ApoB100/100 BMDMs and the spleens of Chr4Δ70kb/Δ70kbLdlr−/−ApoB100/100 and Ldlr−/−ApoB100/100 mice after oxLDL treatment or HFD, respectively. Here, LDLR is linked to atherosclerosis.