Chr4Δ70kb/Δ70kb increased the development of advanced atherosclerotic plaques in an HFD-dependent manner (P = 0.0001; Figure 2A) in Ldlr−/−ApoB100/100 mice after 12 weeks of HFD, whereas there was no effect on atherosclerosis in age-matched mice on standard laboratory diet (Figure 2A). Here, LDLR is linked to atherosclerosis.