In order to further study the function of focal adhesion in COAD, we compared the expression levels of prognostic focal adhesion genes in each sample, and innovatively established ARGP score, and finally identified 4 ARGs signature, CAV2, FLT1, THBS3, and VAV3, we found that patients in the low-risk group had the better OS than that in the higher-risk group. Here, CAV2 is linked to colon adenocarcinoma.