Alzheimer’s disease (AD) is a neurodegenerative condition defined by the gradual death of brain cells through many signaling pathways, including glutamate, PI3K/Akt, extracellular signal-regulated kinase (ERK), HMGB, and Necrotic factor kappa B (NFkB) (Kao et al., 2009; Srinivasan and Lahiri, 2015; Miculas et al., 2022). This evidence concerns the gene NFKB1 and Alzheimer disease.