Recently, the measurement of multiple NEN-related transcripts or the detection of circulating tumor cells has been introduced and will play a key role, and seems to be superior to historical serum markers, such as Chromogranin A. Cross-sectional imaging, combined with somatostatin receptor scintigraphy and PET scan will complement the diagnostic approach and assist in disease stratification. The gene discussed is CHGA; the disease is neoplasm.