Rs5186 in AGTR1 is related to different therapeutic efficacy to CCBs and ACEIs in 311 White Europeans with hypertension (Benetos et al., 1996) whereas associated with ARBs on systolic blood pressure (SBP) response in 1,049 Chinese patients with hypertension (Jiang et al., 2011). This evidence concerns the gene AGTR1 and hypertensive disorder.