We also found that 32 proteins were remarkably changed in both the hippocampus and the cerebral cortex (TBN/AD fold change ≥1.2 or <0.83, Supplementary Table A-S3) including ANXA 7, SODC, COX2 (mt-Co2), COX7C, GRIA2, SRRM2 and SF3B1 (Figure 9). Here, MT-CO2 is linked to Alzheimer disease.