Many hypotheses have been put forward for the pathogenesis of AD, including amyloid-beta (Aβ) cascade, tau pathology, mitochondrial cascade, cholinergic neuron damage, glutamate excitotoxicity, oxidative stress, and neuroinflammation (Ali, 2016; X; Du, Wang, & Geng, 2018). The gene discussed is MAPT; the disease is Alzheimer disease.