According to the two main pathological characteristics of inflammatory cell infiltration and abnormal keratinocyte proliferation in psoriasis, we confirmed that BZLF downregulated the expression of inflammatory factors (Il17a, Tnf-α, and Cxcl1) in psoriasis-like lesions and inhibited the expression of the keratinocyte proliferation marker Ki67. Here, CXCL1 is linked to psoriasis.