EGFR and non-small cell lung carcinoma: Not only was the IFN-γ secretion from the NK cells inhibited by NSCLC cell lines H1975 (EGFR L858R+T790M), but the surface ligands interacting with receptors on NK cells (ULBP1, ULBP2, and MICA) were also downregulated after being co-cultured with H1975 cell line (39).