AKT1 and non-small cell lung carcinoma: Similarly, an enhanced M2-like polarization and migration ability of TAMs in EGFR-MT NSCLC cells were found to be promoted by immunoglobulin-like transcript 4 (ILT4; a key immunosuppressive molecule), which was upregulated via EGFR-AKT/-ERK1/2 signaling (45).