Increased infiltration of CAR T-cells into tumor.Reduction in tumor infiltrating Tregs.Suppression of co-inhibitory receptor (PD-1 & LAG3) expression on T cells.Promotes expression of T-cell recruiting chemokines in tumor cells (CXCL9, CXCL10) and CXCR3 receptors on CAR T cells. The gene discussed is LAG3; the disease is neoplasm.