GSK3B and anxiety disorder: Previously, striatal dopaminergic circuits were implicated in locomotor activity and anxiety disorders (Macpherson and Hikida, 2019; Casado-Sainz et al., 2022), while striatal physiology is affected preferentially by GSK3β inhibition compared with some other brain regions (Gómez-Sintes and Lucas, 2010); thus, the acute side effects may be due to the targeted effects of systemic administration of LiCl on the striatum.