GSK3B and Anxiety: Taken together, these results suggest that, in adulthood, all three GSK3β interventions reduce the adolescent METH exposure-induced long-lasting hyperactivity; but only chronic systemic and chronic within CA1 interventions improve that induced social, object, and spatial recognition memory impairments; in addition, acute Li exposure reduces locomotor activity and leads to anxiety-like behavior; for novel spatial exploration impairment, all three interventions have no significant effects.