Through comparing the methylation roles of DLAT in tumors and normal tissues, we found that the levels of DNA methylation were significantly increased in bladder urothelial carcinoma (BLCA), colon adenocarcinoma (COAD), cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), ESCA, HNSC, prostate adenocarcinoma (PRAD) and rectum adenocarcinoma (READ) (Figs. 2A–2G). The gene discussed is DLAT; the disease is bladder transitional cell carcinoma.