MAPT and tauopathy: In transcriptome data from the original study, tauopathy was associated with increased Gene Ontology evidence of inflammation/immune activation and decreases in signatures of neuronal health and function (much like in our older vs. younger mice), suggesting these mice could be a good model for testing the efficacy of 3TC—although we note that others have reported retrotransposon increases in other tau models as well (Ramirez et al., 2022).