We found that H2BE-Flag-overexpressing cells showed decreased levels of the GRP78 protein (Figures 6A and B), phosphorylated PERK, phosphorylated eIF2 (Figures 6C and D), phosphorylated IRE1 and phosphorylated JNK (Figures 6E and F) 12 h and 24 h after infection, compared to levels in the empty vector group. The gene discussed is MAPK8; the disease is infection.