However, in light of the enrichment for astrocyte proteins identified in some dysregulated modules and their essential role in the viability of neurons, this upregulation may reflect the loss of normal astrocyte function specifically contributing to FTLD-tau pathophysiology, as it has been suggested recently for Alzheimer’s disease and other neurodegenerative conditions [33, 55–57]. Here, MAPT is linked to early-onset autosomal dominant Alzheimer disease.