MAPT and early-onset autosomal dominant Alzheimer disease: We found that proteins upregulated in FTLD-tau were most significantly enriched for genes reported to be upregulated in Alzheimer’s disease (Fig. 4A, “blalock alzheimers disease up” gene set in the CGP database) and in the ageing frontal cortex (Fig. 4A, “lu ageing brain up” gene set in the CPG database).