In addition, our studies found that TSP1 targets included: TAGLN, a regulator of angiogenesis [46], LOXL4, a contributor to the vascular permeability in diabetes [47], types of collagen (COL4A1 and COL8A1) that influence angiogenesis plus THSB1 an inhibitor of angiogenesis [48]. This evidence concerns the gene COL4A1 and diabetes mellitus.