THBS1 and type 2 diabetes mellitus: In a study by Dzhoyashvili et al. [39], MSC harvested from subjects with type 2 diabetes and coronary artery disease showed impaired ability to stimulate angiogenesis in vitro with significant increase in mRNA level of THBS1, as well as closely negative correlation between its mRNA level and MSC angiogenic activity measured by tube formation assay.