In this study, the expression of CXCL8 and CXCL1 in ILC3s upon IL-1β stimulation was insensitive to dexamethasone, suggesting that neutrophilic inflammation mediated by IL-1β-ILC3-CXCL8/CXCL1 axis may be involved in the development of steroid-resistant of asthma. Here, CXCL1 is linked to asthma.