WASF3 and in situ carcinoma: To delve deeper into the relationship between WAVE3 and the chemoresistance phenotype, we devised an in vivo tumor growth experiment, where the parental (CT), cisplatin-resistant (CIS-R) or the cisplatin-resistant MDA-MB-231 cells that were rendered deficient in WAVE3 (CIS-R-W3KO) were orthotopically injected in the mammary fat pads of female NSG mice.