WASF3 and neoplasm: What is noteworthy is that in the mice injected with the WAVE3-deficient (W3-KO) or those re-expressing phosphomutant WAVE3 (W3-Y4), tumors that grew in the doxorubicin-treated group were significantly (p < 0.01) smaller (Fig. 3A) and lighter (Fig. 3B) than those that grew in their respective untreated groups, which strongly suggests a synergistic effect between loss of WAVE3 or its phosphorylation and doxorubicin treatment to inhibit tumor growth.