REN and cancer: In the low-risk subgroup, the enriched KEGG terms mostly concentrated on several metabolism pathways (like Fatty acid metabolism and Propanoate metabolism), various key signal pathways (Hedgehog signaling pathway, Hippo signaling pathway, and Renin-angiotensin system), metastasis-related pathway—Adherens junction pathway and cancer-related signaling pathways—Renal cell carcinoma (Fig. 7D).