For example, it was found that peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC1A), as a lipid metabolic regulator activated by melatonin, promoted tumor slimming, a lipid browning process reducing catabolic state, and inhibited ccRCC metastases through uncoupling protein 1(UCP1)-dependent manner [47]. Here, PPARGC1A is linked to nonpapillary renal cell carcinoma.