SETD2 and nonpapillary renal cell carcinoma: Additionally, ccRCC patients with mutated SETD2 were found to have significantly shortened PFS and DFS compared to SETD2 intact ones implying that mutated SETD2 might promote ccRCC progression, while both the mutated SETD2 and SETD2 intact subgroups possessed similar OS (Supplementary Fig. 5B-D).