PPARGC1A and neoplasm: For example, it was found that peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC1A), as a lipid metabolic regulator activated by melatonin, promoted tumor slimming, a lipid browning process reducing catabolic state, and inhibited ccRCC metastases through uncoupling protein 1(UCP1)-dependent manner [47].