According to TCGA-KIRC cohort, the expression of ENO2, PFKP, PLIN2, TRIB3, RIMKLA, PLOD2, GMPPA, HYI, and GALNT14 elevated, while the expression of ITPKB, METAP1 and GALNT7 declined in ccRCC, in comparison with normal kidney tissue (Supplementary Fig. 6A). This evidence concerns the gene HYI and nonpapillary renal cell carcinoma.