In addition, gut microbiota dysbiosis was observed in C57BL6/J mice administrated with salivary samples from periodontitis patients, with an increased abundance of Porphyromonadaceae and Fusobacterium. In addition, the levels of pro-inflammatory cytokines and chemokines such as IL-1β, IL-6 and colony-stimulating factor 1 were elevated, while the expression of anti-inflammatory cytokines such as IL-10 were decreased in colon tissue [90]. The gene discussed is IL1B; the disease is periodontitis.