The fact that OAS genes were highly expressed in both SARS-CoV-2-infected cardiomyocytes and human failing hearts provides us a reason to believe that some similar signaling molecules and/or pathways may mediate the developments of COVID-19 and HF, or in other words, there may be some similar or common molecular mechanisms in the two diseases, and OAS gene family may be the common genetic factors. The gene discussed is SMOC1; the disease is hydrops fetalis.