However, drug development is lengthy and only a very small fraction of hits are successful and become available as clinical drug treatments.[6] NANOG is an essential induced pluripotent stem cell (iPS) reprogramming factor.[7] Our lab recently showed that NANOG knockdown in mice reduced alcohol, high‐fat‐diet‐mediated HCC development.[2] In this study, we screened an federal drug administration (FDA)‐approved drug library for identification of drug candidates that selectively targeted TICs. Here, NANOG is linked to hepatocellular carcinoma.