On the other hand, the overstimulation of TLR signaling may also drive cancer initiation/progression by provoking the release of proinflammatory cytokines (e.g., TNF-α, IL-1β and IL-6) or antiapoptotic, proliferative, and profibrogenic signaling molecules that contribute to the conversation of normal cells into tumor cells [80]. The gene discussed is TNF; the disease is neoplasm.