In contrast to MyD88-, TRIF- and TLR-knockout mice, in which no defects were observed in spontaneous cross-priming of tumor-specific T cells, STING- and IRF3-deficient mice showed the defective accumulation of antitumor-specific CD8+ T cells in the seminal experiments performed by Woo et al. [90]. Here, IRF3 is linked to neoplasm.