Within the TME, cDCs have been shown to acquire a common gene program characterized by the expression of immunoregulatory genes (e.g., CD274/PD-L1, PDCD1LG2/PD-L2 and CD200), LAMP3 and CCR7, thus informing the naming of these tumor-specific cells mregDCs or LAMP3+CCR7+ cDCs [22, 53]. This evidence concerns the gene PDCD1LG2 and neoplasm.