Patient-derived metastatic PDA samples had larger amounts of MYL6 and CLSTN1 skipped isoforms (lower PSI) compared with primary PDA samples, suggesting that MYL6 exon 6 and CLSTN1 exon 10 skipping contribute to the oncogenic characteristics of metastatic PDA cells (Extended Data Figs. 11b and 12b). Here, MYL6 is linked to Patent ductus arteriosus.