To investigate the role and the mechanisms of resistance to therapy in EMT tumour cells in vivo, we used a genetically induced mouse model of skin SCCs combining the expression of oncogenic Kras (KrasG12D) with the deletion of Trp53 and the expression of a YFP reporter in hair follicle lineages10 (Lgr5creERKrasG12DTrp53cKORosa-YFP). Here, TP53 is linked to neoplasm.