AKT1 and pulmonary fibrosis: An in vitro and an in-vivo study found that the PI3K/Akt signaling pathway is inhabits by digoxin (100 nmol/L and 50 nmol/L in 12 mice model group) which may be able to regulate the activation of fibroblasts and prevent the pulmonary fibrosis that bleomycin-induced in mice145.