MACROD2 and obesity due to melanocortin 4 receptor deficiency: The expression of gene MOXD1 located in locus 6q23.2 for SNP rs9493286 (p = 7.25 × 10–6) has been identified to be associated with diabetic nephropathy and obesity-related traits46–48.Gene MACROD2 located in locus 20p12.1 have been associated with chronic kidney disease, hypertension, glomerular filtration rate, with the leading SNP rs11696648 demonstrating an association (p = 9.05 × 10–6)41,49–51.