MECOM and acute leukemia: Our study adds to the growing literature that enhancer-hijacking in acute leukemia represents an important mechanism for gene deregulation [13], examplarily shown for inv(3)/t(3;3)(q21q26) AML resulting in MECOM activation via relocation of the GATA2 enhancer [14], or for acute leukemias of ambiguous lineage, overexpressing BCL11B due to enhancer hijacking events involving enhancers from CDK6 or ARID1A gene regions [15].