The enriched pathways based on the KEGG database indicated that cardiac disease associated pathways, including “hypertrophic cardiomyopathy (HCM), dilated cardiomyopathy (DCM) and arrhythmogenic right ventricular cardiomyopathy (ARVC)” were enriched in the Mrps5 mutant embryonic hearts (Supplementary Fig. 2g). Here, MRPS5 is linked to hypertrophic cardiomyopathy.