Further metabolic assessment showed that while A/J mice were resistant to diet-induced hyperglycaemia, hyperinsulinaemia (Table S4) and glucose-induced insulin secretion (Fig. 4M), they exhibited mild glucose intolerance (Fig. 4I), and even mild improvements in insulin sensitivity (Fig. 4Q, see Table S4 for glucose disappearance rate for ITT (KITT)). Here, INS is linked to Glucose intolerance.