INS and Insulin resistance: Contrary to our expectations, CBA mice showed improvements in glucose tolerance when fed the NASH diet (Fig. 4J, see Table S4 for area-under-curve (AUC)), potentially related to substantial hyperinsulinaemia and in this respect increased HOMA-IR (Table S4), and increased glucose-induced insulin secretion (Fig. 4N), in the absence of fasting hyperglycaemia (Table S4) or insulin resistance (Fig. 4R, Table S4).