FVB/N mice show high incidence of spontaneous multifocal hepatocellular necrosis35, and exhibit the greatest increase in liver weight, prevalence of periductal fibrosis, highest rates of plasma ALT and substantial hepatocyte ballooning compared to four other mouse strains, when administered an agent that induces Mallory-Denk bodies (i.e., hepatocyte inclusions found in several liver diseases that correlate with hepatocyte ballooning)36, overall indicating that FVB/N mice have a high predisposition to advanced liver disease. The gene discussed is GPT; the disease is liver disorder.