For instance, the ubiquitin ligase STUB1 regulates the stability and activity of RUNX1 in leukemia [45]; RNF38 promotes RUNX1 ubiquitination and enhances RUNX1-mediated erythroid transcriptional program inhibition [46]; while FZR1 regulates ubiquitin-dependent degradation of RUNX1 in aplastic anemia [47]. The gene discussed is RNF38; the disease is leukemia.