A comparison of IGFBP5 expression between normal and tumor tissues from patients with various types of cancer using data from the Gene Expression across Normal and Tumor Tissue (GENT; http://medical-genome.kribb.re.kr/GENT/) database31 showed that IGFBP5 is typically expressed at lower levels in tumor tissues than in normal tissues (Supplementary Fig. 2a, b). Here, IGFBP5 is linked to neoplasm.