The knockdown of IGFBP5 expression in 772 GSCs (Fig. 6c) suppressed GSC invasion (Fig. 6d and Supplementary Fig. 8a), as well as the expression of the target genes ETV5 and FBXW9 (Supplementary Fig. 8b, c), and tumor volume (Fig. 6e), while significantly prolonged the survival of the mouse (Fig. 6f). Here, FBXW9 is linked to neoplasm.