STING1 and neoplasm: To further investigate the functional importance of demethylation-induced STING reactivation in tumor cells in enhancing antitumor responses to STING agonist therapy in a host with intact STING activity, we injected C57BL/6 mice with B16-F10 or Yumm1.7 tumor cells and treated them with a combination of ADU-S100 and 5AZADC (Fig. 8a).