We also found reconstitution of STING protein expression in both B16-F10 and Yumm1.7 cell lines following their treatment with 5AZADC (Fig. 2d, e) further suggesting promoter hypermethylation-driven STING silencing and indicating their similarities in epigenetic regulation of STING to human melanoma cell lines. This evidence concerns the gene STING1 and melanoma.