DNMT3A and melanoma: Additionally, using a publicly available cBioPortal dataset41 we identified a negative, albeit not significant, correlation between STING and DNMT3A (Pearson’s r = −0.41), DNMT3B (Pearson’s r = −0.28) (Fig. 3g), as well as DNMT1 mRNA levels (Pearson’s r = −0.13) (Supplementary Fig. 4b) across metastatic melanoma samples, suggesting their involvement in melanoma-STING silencing.